In 2007, flubenzamide listed, began the diamides insecticide market prologue.
In 2008, the benzamide hit the market, and the product began to take the lead. In the pesticide market, bisamides have attracted much attention and become one of the four important product types. In 2018, sales of neonicotinoids (US $3,007 million) , pyrethroids (US $2,736 million) , Bisamides (US $2,215 million) and organophosphates (US $2,201 million) accounted for 17.3% , 15.8% , 12.8% and 12.7% of the pesticide market respectively. Among them, the annual growth rate of Bisamides and the compound annual growth rate in recent 5 years were the first. Among Bisamides, benzamide is the world's largest pesticide producer, with sales of $1.59 billion in 2018 and an unassailable lead of more than $1.00 billion. Bisamides have attracted a lot of R & D POWER FOR THEIR UNIQUE action mechanism and product characteristics.
New Products continue to appear on the market, and some new products are expected to become the future blockbuster products. At present, the main diamides on the market are flubenzamide (2007) , chlorantraniliprole (2008) , bromocyanamide (2012) , benzamide (2014) , cyclopropylamide (2017) , flubenzamide (2019) , tetrazolium amide (2020) and so on. The development and marketing of these products have injected growth momentum into bisamides. According to Phillips McDougall, global sales of 2023 will grow to $3.115 billion, surpassing current sales of neonicotinoids.
1 The mechanism of action of Bisamides, the main action of Bisamides is fish nicotine receptor, but due to the change of chemical structure, not all products act on fish nicotine receptor. The International Action Committee on Insecticide Resistance (IRAC) classified the fish nicotine receptor modulators as Group 28(IRAC Group 28) , there are currently five compounds in this group: chlorantraniliprole, Benzamide, Cypropionamide, flubenzamide and tetrazolium amide. In addition, tetrachloroformamide, chlorofluorocyanoformamide, thioformamide and so on are also receptor agents for fish nicotine. These products all act on the insect's fish nicotine receptor, causing it to over-release the calcium ions stored in the smooth muscle and striated muscle cells, causing the weakness of the muscle regulation of the insect, affecting the insect's behavior, and causing it to stop feeding rapidly, and eventually killed. However, the mechanisms of action of bromoflubenzamide and ciprofloxacin are different. They are GABA-gated Chloride Channel modulators, which block the normal signal transmission by changing the insect Gaba receptor, so that the pest can not be pacified excitement, to achieve insecticidal effect. IRAC classifies flubenzamide as group 30, the first compound in the group, and the other active ingredient in the group is fluxametamide, an isoxazoline insecticide developed by Nissan Chemical In the future, Syngenta's bisaryl isooxazoline insecticide ISOOXAZOLAM (isocycloseram) and trifluoxetine (Cyhalofluoxetine) will also be included in group 30. Neither the Bisamides, which act on the fish nicotine receptor, nor the Bisamides, which act on the Gaba chloride channel, have cross resistance to other insecticides, it can be used to control the resistance of pests.
2 overview of the diamide pesticide market. According to Phillips McDougall, sales of diamide pesticides were $2.215 billion in 2018, representing a 12.6 per cent year-on-year increase and 3.4 per cent of the $65.099 billion global pesticide market for the year, 12.8 per cent of the $17.340 billion pesticide market; compound annual growth rate of 6.5 per cent in 2013-2018. Of the Bisamides on the market, the top five products account for almost all of the market (table 1) . In particular, Benzamide, with $1.59 billion in sales and a 71.8% market share, has focused strongly on the pesticide industry, attracting manufacturers of generic products to prepare early.
3.1 chlorantraniliprole (common name: CHLORANTRANILIPROLE; Trade Names: Rynaxypyr, Premio, Dermacor, Corozen, etc. ; Development Code: DPX-E2Y45) is a diamide insecticide developed by dupont (now Cortewa) , launched in 2008, Amine is now sold in more than 100 countries, with Latin America and Asia accounting for more than half of it.
Chloranthus benzamide has strong permeability and imbibition conduction through xylem, which is helpful to protect the new tissue. Stomach poison is the main toxicity, contact killing is secondary. The benzamide is highly effective and broad-spectrum, used in soybeans, rice, corn, grains, cotton, potatoes, pears, grapes, Sugar Cane, sunflowers, beets, rape, non-crops, etc. to control most chewing mouthparts pests, especially, it has good control effect on Lepidoptera, Coleoptera, etc. . Leaf treatment, seed treatment and soil treatment could be used, and the amount of effective components was 35 ~ 50 g/hm ~ 2. As a seed treatment agent, the product is widely used in the United States, Brazil, Canada and other countries, such as corn, soybean and other crops. Through the agreement, Syngenta won the right to develop and sell the benzamide compound and use the active ingredient in lawns and termite control. In November 2017, for the Dow and dupont merger, benzamide was spun off to Fumeishi. When benzamide went on the market, its sales quickly topped $1.0 billion. In 2018, its sales rose 13.4 percent from a year earlier to $1.59 billion. The increase was mainly due to the use of the product as a seed treatment agent for genetically modified crops, as well as strong market drivers in developing countries; the recovery of inventory levels in Brazil also contributed significantly to the increase in sales of the product. The compound annual growth rate of benzamide was 9.0% from 2013 to 2018.
Based on its excellent product performance, chloranterbenzoamide is being developed as a blended preparation and continues to be developed into new markets (such as seed treatment, off-farm use, etc.), and its future market growth potential is maintained, thus defending its dominance in the global pesticide market. (1) In 2017, DuPont and Allistar announced a partnership to develop a combination product of DuPont's chlorantranamide and Allistar's acetamiprid. Soon after, however, DuPont announced that it was spinning off chloranterbenzamide to FormerHarvest. (2) In November 2017, Formercorp completed the acquisition of chloranterbenzoamide. This includes intellectual property related to the acquired products, such as patents, registrations, etc., as well as the global manufacturing network supporting these products, such as 4 active ingredient manufacturing plants, 10 regional pharmaceutical processing plants, etc. (3) In 2018, Formerance launched Altacor, a product based on chloranzobenzoamide for brassica and gourd, in Italy. In 2019, the product Acelepryn based on chloranterbenzoamide developed by Syngenta was registered in the United States for use in nurseries and greenhouses of ornamental plants, etc. (5) The registration of Encore Box GR(Trichlorobenzamide Trifluoropyrimidine Tricyclazole), a tri-compound product of combinational chemistry, was approved in the fiscal year 2019.
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